451 4.7.1 Received too many messages from a new or untrusted IP: #.#.#.#
In order to combat spam the mail platform performs an "IP reputation check" on incoming mail which checks the validity and health of the IP addresses sending emails to users within the mail environment.
How to fix this error?
The sender of the email or their email provider needs to review and implement the best practices listed in this article entitled "Sending to Us": https://postmaster.emailsrvr.com/sending-to-us
Note: Unfortunately, adding the IP or sending user to a whitelist on our side does not guarantee the bypassing of this reputation check due to the fact that the reputation check is done BEFORE the mail reaches the internal mail environment.